NDLI: Antioxidation effects of rosmarinic acid on human skin melanoma cells treated with hydrogen peroxide

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Journal of the Korean Society for Applied Biological Chemistry : Volume 52, Issue 2, April 2009

Journal of the Korean Society for Applied Biological Chemistry : Volume 52, Issue 1, February 2009

Antioxidation effects of rosmarinic acid on human skin melanoma cells treated with hydrogen peroxide

Content Provider	Springer Nature Link
Author	Yoo, Sun Mi Kang, Jeong Ran
Copyright Year	2003
Abstract	The purpose of this study was to evaluate the antioxidant effect of rosmarinic acid on the cultured human skin melanoma cells injured by reactive oxygen species. The cytotoxicity and antioxidant effect were analyzed by XTT assay for cell adhesion activity, DPPH-radical scavenging activity, lactate dehydrogenase (LDH) activity after treated of cells with or without hydrogen peroxide (H$_{2}$O$_{2}$) for 1–10 h. H$_{2}$O$_{2}$ decreased the cell adhesion activity in cultured human melanoma cells in a dose- and time-dependent manner after cells were treated with 20–110 ώM of H$_{2}$O$_{2}$ for 5–7 h. IC$_{50}$ values of H$_{2}$O$_{2}$ by XTT assay were 90 ώM, respectively. H$_{2}$O$_{2}$ increased LDH activity dose dependently. LDH$_{50}$ was determined at 60 ώM H$_{2}$O$_{2}$ after treatment of cells with 50–90 ώM H$_{2}$O$_{2}$ for 8 h. Rosmarinic acid increases cell adhesion activity, DPPH-radical scavenging and decreases LDH activity. The treatment of the cells with H$_{2}$O$_{2}$ shows highly toxic effects on cultured human skin melanoma cells. Rosmarinic acid increases cell adhesion activity, DPPH-radical scavenging activity and decreases LDH activity in the cells treated with H$_{2}$O$_{2}$. It is considered that rosmarinic acid shows antioxidant effect on ROS such as H$_{2}$O$_{2}$.
Starting Page	247
Ending Page	251
Page Count	5
File Format	PDF
ISSN	17382203
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume Number	52
Issue Number	3
e-ISSN	2234344X
Language	English
Publisher	Springer-Verlag
Publisher Date	2003-01-01
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	DPPH-radical scavenging LDH Applied Microbiology Biological Techniques rosmarinic acid XTT assay Bioorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry, Genetics and Molecular Biology

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