NDLI: Butyrate and propionate, short chain fatty acids, attenuate myocardial damages by inhibition of apoptosis in a rat model of ischemia-reperfusion

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Journal of the Korean Society for Applied Biological Chemistry : Volume 53, Issue 4, August 2010

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Butyrate and propionate, short chain fatty acids, attenuate myocardial damages by inhibition of apoptosis in a rat model of ischemia-reperfusion

Content Provider	Springer Nature Link
Author	Lee, Jongwon Lim, Sun Ha Song, Kyung Sik
Copyright Year	2003
Abstract	Dietary fiber (DF) and resistant starch (RS) in the grains of cereals are fermented into short chain fatty acids (SCFA), including butyrate, propionate, and acetate, in the large intestine, and are absorbed into the blood. Effectiveness of SCFA in reducing myocardial damage was evaluated in a rat model of 30 min ischemia and 3 h reperfusion with administration of SCFA (10 mg/kg) by peritoneal injection 1 h before occlusion. Butyrate and propionate significantly attenuated infarct size, an indicator of myocardial damage, when assessed by 2,3,5-triphenyltetrazolium chloride staining, reduced apoptosis in terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling staining, and increased Bcl-2/Bax ratio, a determinant of cell survival in the apoptotic pathway. In addition, butyrate significantly attenuated the level of caspase-3, an executioner caspase, in an immunohistochemical assay. These results demonstrate that butyrate and propionate, produced by fermentation of DF and RS in the large intestine, could prevent myocardial infarction by attenuating apoptosis, possibly through inhibition of histone deacetylases. Thus, varieties of cereals or diets that produce a large amount of butyrate and propionate by fermentation could be beneficial in reducing myocardial infarction.
Starting Page	570
Ending Page	577
Page Count	8
File Format	PDF
ISSN	17382203
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume Number	53
Issue Number	5
e-ISSN	2234344X
Language	English
Publisher	Springer-Verlag
Publisher Date	2003-01-01
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	butyrate histone deacetylase inhibitor myocardial infarction Applied Microbiology apoptosis Biological Techniques propionate short chain fatty acids Bioorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry, Genetics and Molecular Biology

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