NDLI: Efficacy of combination therapy with erythropoietin and methylprednisolone in clinical recovery of severe relapse in multiple sclerosis

Content Provider	Springer Nature Link
Author	Azimi, Amir Reza Rezaei, Nima Najmi Varzaneh, Fatemeh Sahraian, Mohammad Ali Najmi Varzaneh, Farnaz
Copyright Year	2014
Abstract	Multiple sclerosis (MS) is a multifaceted disease in which genetic and environmental factors are involved. Although neurodegeneration aspect of MS has major influence in patients’ disability, none of the available treatments have been shown to obviously reduce neurodegeneration. Recently, the role of Erythropoietin (EPO) as a neuroprotective and anti-inflammatory agent has been attracted tremendous interest. In the present randomized double-blind pilot study, we combined EPO with methylprednisolone (MPred) in severe motor relapsing–remitting MS (RR-MS) patients to target both inflammatory and neurodegenerative aspects of disease. Twenty patients with RR-MS in relapse phase were randomized into two groups. The case group (10 patients) received intravenous MPred (1,000 mg/24 h) and intravenous EPO (20,000 U/24 h) for five consecutive days, and the control group (10 patients) received just MPred at the same dose as the case group, and a placebo. Both groups were followed for 3 months by ambulatory index (AI), Expanded Disability Status Scale (EDSS) and by magnetic resonance imaging (MRI) parameters. Improvement in maximal distance walking, reflected by reduction in AI and EDSS, was observed in EPO group after second month and continued after 3 months. Furthermore, MRI data analysis showed significant reduction in the number of T2WI lesions in EPO group without any significant change in contrast enhancing and black hole lesions. There was no major side effect in EPO group. The results of this first therapeutic pilot trial in RR-MS patients are promising, but need to be validated in larger trials.
Starting Page	273
Ending Page	278
Page Count	6
File Format	PDF
ISSN	03009009
Journal	Acta Neurologica Belgica
Volume Number	114
Issue Number	4
e-ISSN	22402993
Language	English
Publisher	Springer Milan
Publisher Date	2014-03-07
Publisher Place	Milan
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neurology Multiple sclerosis Neurosciences Treatment Erythropoietin Medicine/Public Health Methylprednisolone Neuroradiology
Content Type	Text
Resource Type	Article
Subject	Neurology (clinical)

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