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| Content Provider | Springer Nature Link |
|---|---|
| Author | Farzan, Maryam Rostami, Mahboubeh Maaleki, Sahar Khodarahmi, Ghadam Ali Hassanzadeh, Farshid Varshosaz, Jaleh |
| Copyright Year | 2016 |
| Abstract | A novel thermosensitive folic acid (FA)-targeted succinylated poly (ethylene-co-vinyl alcohol) (EVOH) (EVOHS-FA) nanocarrier was synthesized for the specific delivery of epirubicin (EPI) to MCF-7 breast cancer cell line. Three different ratios of synthesized EVOH-Suc were reacted with FA. The structure of the desired products (EVOHS$_{40}$-FA, EVOHS$_{60}$-FA and EVOHS$_{80}$-FA) was confirmed by $^{1}$H NMR and FTIR techniques. Nanoparticles were obtained by nano-precipitation procedure using DMSO/H$_{2}$O as solvent/anti-solvent. The particle size, zeta potential, entrapment efficacy and in vitro release profile of the final formulations in different temperatures were measured. The optimized nanoparticles had the particle size of 214 ± 8.5 nm, zeta potential of −29.6 mV, PDI of 0.198 ± 0.04, and a high encapsulation efficiency that released the drug efficiently within 450 h at the temperature of 40 °C compared to 37 °C. The morphology of nanoparticles was studied by scanning electron microscopy. The in vitro cytotoxicity was evaluated using the MTT assay on MCF-7 cell lines in response to temperatures of 37 and 40 °C. The MTT assay indicated that the targeted nanoparticles carrying EPI were significantly more cytotoxic than the non-targeted nanoparticles and the free drug at 40 °C. |
| Starting Page | 967 |
| Ending Page | 976 |
| Page Count | 10 |
| File Format | |
| ISSN | 10261265 |
| Journal | Iranian Polymer Journal |
| Volume Number | 25 |
| Issue Number | 11 |
| e-ISSN | 17355265 |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2016-10-12 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Polymer Sciences Thermosensitive Epirubicin (EPI) Targeted polymeric nanoparticles EVOH Breast cancer Ceramics, Glass, Composites, Natural Materials |
| Content Type | Text |
| Resource Type | Article |
| Subject | Materials Chemistry Chemical Engineering Polymers and Plastics |
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