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| Content Provider | Springer Nature Link |
|---|---|
| Author | Pană, Ana Maria Bandur, Geza Sfirloagă, Paula Popa, Marcel Rusnac, Lucian Mircea Silion, Mihaela Duchatel, Lucie |
| Copyright Year | 2017 |
| Abstract | Hydrogel-based drug delivery systems encounter great scientific attention nowadays. Semi-interpenetrating network systems with hydrogel features have been studied as potential drug carriers due to their water intake capacity, biocompatibility and biodegradability. One of the most important features of drug delivery systems is biocompatibility and as such materials derived from natural resources seem to be more appropriate to act as excipients. In this respect, two new semi-interpenetrating networks (semi-IPNs) with hydrogel features based on chitosan, two novel oligomers derived from monosaccharides and 2-hydroxyethylmethacrylate (HEMA) have been synthesized and characterized using FTIR, thermogravimetry, SEM/EDX and swelling behavior. The new sugar-derived oligomers (GI and MI) with double bonds available for further polymerization were obtained by polycondensation of 1,3-propanediol with dicarboxylic acids derived from glucose/mannose skeleton with itaconic anhydride moieties. GI and MI oligomers were characterized by FTIR, NMR spectroscopy and ESI–MS spectrometry, which showed molecular weights of about 7000 Da and linear polymerization chain structure. The new semi-IPNs show good thermal behavior and these hydrogels display a swelling tendency by loading significantly more water in an acid environment than in a neutral solution. Moreover, these superabsorbent hydrogels are able to load significant amount of hydrosoluble active principle (herein the antibiotic levofloxacin) and their releasing profile is marked by an important “burst effect”. |
| Starting Page | 743 |
| Ending Page | 751 |
| Page Count | 9 |
| File Format | |
| ISSN | 10261265 |
| Journal | Iranian Polymer Journal |
| Volume Number | 26 |
| Issue Number | 10 |
| e-ISSN | 17355265 |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2017-08-30 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | HEMA Polymer Sciences Levofloxacin Monosaccharide oligomer Chitosan Semi-IPN Ceramics, Glass, Composites, Natural Materials |
| Content Type | Text |
| Resource Type | Article |
| Subject | Materials Chemistry Chemical Engineering Polymers and Plastics |
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