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Computational analysis of xanthine dehydrogenase enzyme from different source organisms

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Computational analysis of xanthine dehydrogenase enzyme from different source organisms

Content Provider	Springer Nature Link
Author	Mishra, Sarad Kumar Arora, Shikha Dwivedi, Vivek Dhar Kumar, Akash
Copyright Year	2013
Abstract	In this communication, 30 full length protein sequences of xanthine dehydrogenase enzyme from different species of fungi, bacteria and animals were retrieved from GenPept database and subjected to computational analysis including multiple sequence alignment (MSA), phylogenetic analysis, motif identification, domain identification and discovering individual amino acid composition. MSA revealed that thirteen glycine, three aspartic acid, three glutamic acid, three glutamine, three alanine, two arginine, one valine, one phenylalanine, one tyrosine, one proline, one serine and one asparagine residues which were identically conserved in all analyzed species. Two major sequence clusters were obtained by phylogenetic analysis. One cluster was of animal and fungal origin whereas the other one was of bacterial origin. The amino acid composition results revealed that average frequency of alanine was 9.24 %, which was higher in comparison to other amino acids average frequency. Average frequency of tryptophan residue was 0.84 %, which was very low in all analyzed species. Six domains were identified but only two domains were conserved in all the sequences of bacteria, fungi and animals. These domains were found to be responsible for the functional activity of xanthine dehydrogenase enzyme. In addition, some motifs which were unique for their groups were also identified.
Starting Page	185
Ending Page	189
Page Count	5
File Format	PDF
ISSN	21926662
Journal	Network Modeling Analysis in Health Informatics and Bioinformatics
Volume Number	2
Issue Number	4
e-ISSN	21926670
Language	English
Publisher	Springer Vienna
Publisher Date	2013-02-27
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Phylogenetic analysis Domains Computational Biology/Bioinformatics Motifs Xanthine dehydrogenase Complex Networks Health Informatics MSA Conserved regions Bioinformatics
Content Type	Text
Resource Type	Article
Subject	Urology

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