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| Content Provider | Springer Nature Link |
|---|---|
| Author | Chandra, Phool Kishore, Kamal Ghosh, Ashoke Kumar |
| Copyright Year | 2015 |
| Abstract | Calendula officinalis has been traditionally used in India for treating wounds, ulcers, herpes, scars, skin damage, frostbite and blood purification. Present study was aimed to evaluate antacid capacity in-vitro and antiulcer activity of extract from Calendula officinalis L. (family: Asteraceae) in experimental rats. Evaluation of ethanol extract (100 and 200 mg/kg, orally) from Calendula officinalis (ECO) as antisecretory and in-vivo antacid capacity were carried out by pyloric ligation induced ulcer model. The gastroprotective effect was carried out by absolute ethanol induced ulcer and indomethacin induced ulcer model. Integrity of gastric mucosa was evaluated by the estimation of glutathione (GSH) and gastric mucus level. The in-vitro antacid capacity was evaluated by titration method. ECO produced significant inhibition of ulcer index in all models of ulcers and comparable to standard. The in- vitro antacid capacity was found as 20.58 ± 0.08 mEq/g of ECO. The total protein and pepsin level were found as 92.45 ± 1.89 μg/ml and 34.67 ± 1.25 μmole/ml, respectively in pylorus ligation model at 200 mg/kg of ECO. GSH level were significant elevated by 200 mg/kg of ECO (P < 0.01) in indomethacin induced ulcers and shows superiority over standard drug (P < 0.05). Gastric wall mucus level was increased in all three models of ulcers and comparable to the ranitidine. We believe that the antiulcer activity of Calendula officinalis was due to its antisecretory and gastroprotective effect on experimental rats. Our results contribute towards validation of the traditional use of Calendula officinalis in the treatment ulcers. |
| Starting Page | 277 |
| Ending Page | 285 |
| Page Count | 9 |
| File Format | |
| ISSN | 15982386 |
| Journal | Oriental Pharmacy and Experimental Medicine |
| Volume Number | 15 |
| Issue Number | 4 |
| e-ISSN | 22111069 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2015-10-02 |
| Publisher Place | Dordrecht |
| Access Restriction | Subscribed |
| Subject Keyword | Calendula officinalis Pylorus ligation Indomethacin induced ulcer Ethanol induced ulcer Biomedicine general Pharmacy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Complementary and Alternative Medicine |
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