NDLI: Genistein-4′-O-α-L-rhamnopyranosyl-(1→2)- β-D-glucopyranoside from Sophora japonica (Leguminosae) ameliorates mast cell-mediated allergic inflammation in vivo and in vitro

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Genistein-4′-O-α-L-rhamnopyranosyl-(1→2)- β-D-glucopyranoside from Sophora japonica (Leguminosae) ameliorates mast cell-mediated allergic inflammation in vivo and in vitro

Oriental Pharmacy and Experimental Medicine : Volume 11, Issue 2, August 2011

Oriental Pharmacy and Experimental Medicine : Volume 11, Issue 1, March 2011

Genistein-4′-O-α-L-rhamnopyranosyl-(1→2)- β-D-glucopyranoside from Sophora japonica (Leguminosae) ameliorates mast cell-mediated allergic inflammation in vivo and in vitro

Content Provider	Springer Nature Link
Author	Kim, Su Jin Kim, Ye Jin Lee, Jae Ho Oh, Sa Rang Park, Chan Ik Jeong, Ji Wook Um, Jae Young Hong, Seung Heon Ahn, Eun Mi
Copyright Year	2011
Abstract	Genistein-4′-O-α-L-rhamnopyranosyl-(1–2)- β-D-glucopyranoside (GRG) is one of constituents isolated from Sophora japonica (Leguminosae). It is known to exert various effects such as anti-inflammatory effect. However, the anti-allergic effects of GRG and its molecular mechanisms have yet to be clearly elucidated. In this study, we attempted to evaluate the effects of GRG on mast cell-mediated allergic inflammation in vitro and in vivo. We investigated to ascertain the pharmacological effects of GRG on compound 48/80-induced systemic anaphylaxis and experimental scratching behavior in mice. Additionally, to find a possible explanation for the anti-allergic mechanisms of GRG, we evaluated the regulatory effects of GRG on the level of inflammatory mediators in phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated human mast cells (HMC-1). The finding of this study demonstrated that GRG reduced compound 48/80-induced systemic anaphylaxis and scratching behavior in mice. Additionally, GRG inhibited the production of tumor necrosis factor (TNF)-α, interleukin (IL)-8 and histamine as well as the activation of caspase-1 in PMACI-stimulated HMC-1. Taken together, the findings of this study provide a novel insight into the pharmacological actions of GRG as a potential molecule for use in the treatment of allergic inflammation diseases.
Starting Page	207
Ending Page	213
Page Count	7
File Format	PDF
ISSN	15982386
Journal	Oriental Pharmacy and Experimental Medicine
Volume Number	11
Issue Number	3
e-ISSN	22111069
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-10-28
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Genistein-4′-O-α-L-rhamnopyranosyl-(1–2)- β-D-glucopyranoside Interlukin-8 Mast cells Histamine Caspase-1 Allergic inflammation Pharmacy Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Complementary and Alternative Medicine

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