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| Content Provider | Springer Nature Link |
|---|---|
| Author | Belmouhoub, Messaoud Bribi, Noureddine Iguer ouada, Mokrane |
| Copyright Year | 2016 |
| Abstract | The aim of the present study was to evaluate the antihyperglycemic effect of flavonoids rich fractions of Rosmarinus officinalis L. namely n-butanol fraction (BUT) and diethyl ether fraction (D.E). Antihyperglycemic action was studied in vitro through the inhibitory tests on α-glucosidase of Saccharomyces cerevisiae. In vivo, the antidiabetic effects were tested in both normal and streptozotocin (STZ) induced diabetic mice using various tests including: the decrease of post prandial hyperglycemia, oral glucose tolerance test (OGTT), hypoglycemic effect and inhibition of glucose intestinal transporters. The in vitro α-glucosidase inhibition activity showed that both fractions (BUT and D.E) presented a potent effect. The maximum inhibition with D.E and BUT fractions was, 77 and 72% at 250 μg/ml, respectively. In vivo, BUT fraction at 800 mg/kg, showed a significant impact on post prandial hyperglycemia with 40.77% and 28.2% as a maximum glucose level reduction using sucrose and maltose, respectively. In OGTT, the maximum antihyperglycemic effect (51.65%) was also obtained with BUT fraction at 800 mg/kg. When testing the impact on glucose intestinal transport, a dose of 800 mg/kg of D.E fraction exhibited a significant inhibition with 24.12% as a maximum reduction. The present results clearly demonstrated the complementary effect of Rosmarinus officinalis flavonoids rich fractions, resulting to α-glucosidase inhibition and to antihyperglycemic action through glucose transport inhibition and blood glucose level reduction. |
| Starting Page | 29 |
| Ending Page | 39 |
| Page Count | 11 |
| File Format | |
| ISSN | 15982386 |
| Journal | Oriental Pharmacy and Experimental Medicine |
| Volume Number | 17 |
| Issue Number | 1 |
| e-ISSN | 22111069 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2016-12-28 |
| Publisher Place | Dordrecht |
| Access Restriction | Subscribed |
| Subject Keyword | Rosmarinus officinalis OGTT Intestinal glucose transport Streptozotocin Diabetic mice Postprandial hyperglycemia Biomedicine Pharmacy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Complementary and Alternative Medicine |
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