NDLI: Identification and characterization of phenolic compounds in hydro methanolic extract of Achyranthes aspera (HMEA) by UPLC and MALDI-TOF-MS and in vivo antioxidant activity

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Identification and characterization of phenolic compounds in hydro methanolic extract of Achyranthes aspera (HMEA) by UPLC and MALDI-TOF-MS and in vivo antioxidant activity

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Oriental Pharmacy and Experimental Medicine : Volume 12

Oriental Pharmacy and Experimental Medicine : Volume 11

Identification and characterization of phenolic compounds in hydro methanolic extract of Achyranthes aspera (HMEA) by UPLC and MALDI-TOF-MS and in vivo antioxidant activity

Content Provider	Springer Nature Link
Author	Narayan, Chandradeo Kumar, Arvind
Copyright Year	2012
Abstract	Achyranthes aspera is an omnipresent herb of medicinal herbal group, used traditionally as medicine to cure different types of diseases. The components of hydro-methanolic extract of Achyranthes aspera (HMEA), are screened and tentatively identified using UPLC-PDA and MALDI-TOF-MS techniques. The phenolic compounds tentatively identified are quinic acid (m/z 192.040), chlorogenic acid (m/z 354.0894), kaempferol (m/z 286.0917), quercetin (m/z 302.0895) and chrysin (m/z 254.0654) present in the various ratios in which concentration level of chlorogenic acid and kaempferol are determined considering their peak intensity. To the best of our knowledge this is the first report on the characterization of HMEA using UPLC and MALDI-TOF-MS techniques to demonstrate the presence of various phenolic compounds and their antioxidant enzymes activity in vivo. The enzymes which showed increased activity are GST, GR, CAT, and SOD while activity of LDH decreased. These phenolic compounds have potential to be used as anti-cancerous molecules.
Starting Page	51
Ending Page	59
Page Count	9
File Format	PDF
ISSN	15982386
Journal	Oriental Pharmacy and Experimental Medicine
Volume Number	13
Issue Number	1
e-ISSN	22111069
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-10-02
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Achyranthes aspera HMEA UPLC MALDI-TOF-MS Phenolic compounds Antioxidant activity Biomedicine general Pharmacy
Content Type	Text
Resource Type	Article
Subject	Complementary and Alternative Medicine

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