NDLI: Inhibition of chemokine, interleukin-8 expression in an atopic milieu by Pyeongwee-San extract (KMP6)

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Inhibition of chemokine, interleukin-8 expression in an atopic milieu by Pyeongwee-San extract (KMP6)

Content Provider	Springer Nature Link
Author	Jin, Se Eun Moon, Phil Dong Koh, Jong Ho Lim, Hun Sun Kim, Hyung Min Jeong, Hyun Ja
Copyright Year	2011
Abstract	Interleukin (IL)-8 (CXCL8) expression has been found to be increased in mast cells in atopic dermatitis. It is the most important chemoattractant for immune cells. Pyeongwee-San is a traditional Korean medicine which has been using as a useful prescription for treatment of atopic dermatitis. The objective of this study was to determine precisely the effect of Pyeongwee-San extract (KMP6) on IL-8 expression using human mast cell line, HMC-1 cells. KMP6, HS-Pyeongwee-San (HS-PS, an over-the-counter drug of the Han Kook Shin Yak Pharmaceutical Co., LTD.), and the important component of KMP6, hesperidin inhibited the phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced IL-8 secretion and mRNA expression in HMC-1 cells. These effects were better than those of dexamethasone, the reference drug tested in our experimental model. Our results revealed the effect of KMP6, which may act as a promising therapeutic agent for the treatment of atopic dermatitis.
Starting Page	71
Ending Page	76
Page Count	6
File Format	PDF
ISSN	15982386
Journal	Oriental Pharmacy and Experimental Medicine
Volume Number	11
Issue Number	1
e-ISSN	22111069
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-03-24
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Pyeongwee-San (KMP6) Chemokine Interleukin-8 Atopic dermatitis Biomedicine general Pharmacy
Content Type	Text
Resource Type	Article
Subject	Complementary and Alternative Medicine

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