NDLI: Establishment of a new cell line of endometrioid carcinoma of the ovary and its chemosensitivity

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Establishment of a new cell line of endometrioid carcinoma of the ovary and its chemosensitivity

Content Provider	Springer Nature Link
Author	Umezu, Tomokazu Kajiyama, Hiroaki Terauchi, Mikio Shibata, Kiyosumi Ino, Kazuhiko Nawa, Akihiro Kikkawa, Fumitaka
Copyright Year	2007
Abstract	A new cell line (NOE) of human ovarian endometrioid carcinoma was established and characterized. The cell line showed a short spindle-shaped morphology and continued to grow for more than 4 months without contact inhibition. The doubling time was approximately 15.5 h at the 10th passage. The chromosome number was aneuploid. The IC50 values of paclitaxel, cisplatin and carboplatin were 26.4 ng/mL, 2.4 μg/mL and 32.5 μg/mL, respectively. The NOE cells expressed estrogen receptor α. In nude mice, we confirmed tumor formation of NOE cells. These results indicated that NOE cells showed similar chemosensitivity and properties to those of the original tumor and might be useful in basic studies on the diagnosis, treatment and etiology of ovarian tumors.
Starting Page	71
Ending Page	76
Page Count	6
File Format	PDF
ISSN	09147470
Journal	Human Cell
Volume Number	20
Issue Number	3
e-ISSN	17490774
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-08-06
Publisher Place	Tokyo
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	chemosensitivity endometrioid carcinoma establishment nude mouse ovarian carcinoma Cell Biology Embryology Oncology Stem Cells Reproductive Medicine Cell Culture
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Cancer Research

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