NDLI: Donor age-dependent acceleration of cellular aging by repeated ultraviolet A irradiation of human dermal fibroblasts derived from a single donor

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Donor age-dependent acceleration of cellular aging by repeated ultraviolet A irradiation of human dermal fibroblasts derived from a single donor

Content Provider	Springer Nature Link
Author	Naru, Eiji Ohta, Toshiro Inomata, Ken Hayashi, Akinobu Kaji, Kazuhiko
Copyright Year	2009
Abstract	The relationship between cellular aging and aging of entire organisms has been studied extensively. The findings are confusing, however, and no clear relationships have been demonstrated. The conflicting data may be due to individual differences among the donors of the studied cells. It is crucial to identify the changes in cellular properties that are the result of the aging process. Here, we used human dermal fibroblast cell lines established from a single donor at different ages to assess the influence of ultraviolet A (UVA) on cellular aging. These cell lines have the same genetic background and were obtained from a restricted body region. The results indicated that cellular aging was accelerated by UVA irradiation in a donor age-dependent manner. The ratio of lifespan shortening increased with donor age. Increased donor age not only decreased cell division, but also increased the growth arrest response to UVA irradiation. The characteristics of the cultured cells reflected the age-related changes in dermal fibroblasts.
Starting Page	31
Ending Page	37
Page Count	7
File Format	PDF
ISSN	09147470
Journal	Human Cell
Volume Number	22
Issue Number	2
e-ISSN	17490774
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-08-06
Publisher Place	Tokyo
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	donor age fibroblast in vitro aging Cell Biology Embryology Oncology Stem Cells Reproductive Medicine Cell Culture
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Cancer Research

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