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Rheological study of hyaluronic acid derivatives

Content Provider	Springer Nature Link
Author	Chernos, Michael Grecov, Dana Kwok, Ezra Bebe, Siziwe Babsola, Oladunni Anastassiades, Tassos
Copyright Year	2017
Abstract	The viscoelastic properties of four novel, low molecular weight hyaluronic acid derivatives were investigated and compared to the parent hyaluronic acid compound. Briefly, all derivatives were synthesized by first deacetylating the parent hyaluronic acid. One sample was left as such, while two others were reacytelated. The final compound, of particular interest for its anti-inflammatory properties, was butyrylated. The compounds were dissolved in phosphate buffer solution (PBS) and studied at a concentration of 5 mg/mL. Shear thinning behaviour was observed for all compounds, however, derivative samples had a lower viscosity than the parent compound at high shear rates. Viscoelastic properties were also observed to decrease as a result of the derivative preparation method. It is believed that these changes are primarily caused by a decrease in hyaluronic acid molecular weight. By increasing the concentration of the anti-inflammatory compound, it may be possible to modulate the viscoelastic properties to more closely resemble those of commercial viscosupplements. As a result, an anti-inflammatory derivative of hyaluronic acid may potentially improve upon existing viscosupplements used to treat patients who are susceptible to flare up.
Starting Page	17
Ending Page	24
Page Count	8
File Format	PDF
ISSN	20939868
Journal	Biomedical Engineering Letters
Volume Number	7
Issue Number	1
e-ISSN	2093985X
Language	English
Publisher	The Korean Society of Medical and Biological Engineering
Publisher Date	2017-01-17
Publisher Place	Korea
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Shear thinning Viscoelastic Viscosupplement Anti-inflammatory Osteoarthritis Biomedical Engineering Biological and Medical Physics, Biophysics Biomedicine Medical and Radiation Physics
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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