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| Content Provider | Springer Nature Link |
|---|---|
| Author | Wihastuti, Titin Andri Sargowo, Djanggan Heriansyah, Teuku Rahmawati, Grace Sulfia, Yuni Hendrati |
| Copyright Year | 2015 |
| Abstract | This research aims to find out the levels of xanthone in mangosteen pericarp extract (MPE) and to prove the ability of xanthone in modulating the activity of paraoxonase-1 (PON-1), reduce oxidized-low density lipoprotein (ox-LDL) and increase the levels of acetylcholinesterase (AChE) serum in animal model with organophosphat subchronic and subcutaneous exposure. This research is a true experimental laboratory with in vivo approach to post-test with control group, using 25 animal models of Wistar strain of Rattus novergicus, were exposed to dichlorvos as organophosphates (2 mg/kgBW/day) for 21 days. Those animal models are divided into no exposure group, organophosphate exposure group, and organophosphate exposure plus administration of xanthone groups. The parameters (levels of PON-1, ox-LDL and AChE measured by ELISA Test. The results showed that administration of xanthone significantly increased the levels of AChE, decreased levels of ox-LDL and PON-1. |
| Starting Page | 136 |
| Ending Page | 142 |
| Page Count | 7 |
| File Format | |
| ISSN | 20059752 |
| Journal | Toxicology and Environmental Health Sciences |
| Volume Number | 7 |
| Issue Number | 2 |
| e-ISSN | 22337784 |
| Language | English |
| Publisher | Korean Society of Environmental Risk Assessment and Health Science |
| Publisher Date | 2015-08-04 |
| Publisher Place | Seoul |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | PON-1 ox-LDL AChE Mangosteen pericarp extract Xanthone Organophosphat Pharmacology/Toxicology Environmental Health |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Toxicology |
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