NDLI: Acute dermal and ocular irritation testing of rice bran supercritical CO$_{2}$ extract (RB-SCE) and 0.5% RB-SCE essence product

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Acute dermal and ocular irritation testing of rice bran supercritical CO$_{2}$ extract (RB-SCE) and 0.5% RB-SCE essence product

Content Provider	Springer Nature Link
Author	Choi, Jae Suk Moon, Jin Nam Moon, Woi Sook Cheon, Eun Jin Kim, Joo Wan Kim, Mi Ryung
Copyright Year	2015
Abstract	This study was conducted to investigate the acute dermal and ocular irritation potential of rice bran supercritical CO$_{2}$ extract (RB-SCE) and a 0.5% RB-SCE essence product in rabbits and guinea pigs. No abnormal clinical signs attributable to RB-SCE were detected. In the dermal irritation test, erythema, eschar, and edema formation was observed at 24 h of RB-SCE treatment, and the skin returned to normal after 72 h. The dermal primary irritation index (PII) of RB-SCE was 2.71; thus it was classified as a moderate irritant. In the ocular irritation test, there were no clinical signs related to the application of the RB-SCE; thus it was classified as a non-irritant according to the Draize scoring system. In a skin sensitivity test in rabbits, no abnormal clinical signs attributable to RB-SCE essence were observed and the PII was 0 because there was no evidence of erythema, eschar, or edema. In the guinea pig skin sensitivity test, no abnormal body weight changes or increased mortality was detected. Sensitization to the RB-SCE essence was 0%; thus it was classified as a very weak irritant.
Starting Page	65
Ending Page	72
Page Count	8
File Format	PDF
ISSN	20059752
Journal	Toxicology and Environmental Health Sciences
Volume Number	7
Issue Number	1
e-ISSN	22337784
Language	English
Publisher	Korean Society of Environmental Risk Assessment and Health Science
Publisher Date	2015-04-12
Publisher Place	Springer
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Rice bran Supercritical CO$_{2}$ extract Dermal irritation test Ocular irritation test Pharmacology/Toxicology Environmental Health
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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