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| Content Provider | Springer Nature Link |
|---|---|
| Author | Kim, Eunjoo Lee, Sung Jun Kim, Hyun Chul Lee, Se Geun Go, Tae Jung Baek, Chul Su Jeong, Sang Won |
| Copyright Year | 2009 |
| Abstract | Molecularly imprinted polymer (MIP) was synthesized to selectively detect estrogen-like chemicals depending on their shapes and binding characteristics to Estrogen Receptor (ER) active site. MIP was synthesized on self-assembled monolayer (SAM) formed by thiol-acrylate photopolymerization on Surface Plasmon Resonance (SPR) chip. The imprinting factor was calculated based on the shift of SPR angle at which the excitation of surface plasmons by light was minimum level. The imprinting factor, 4.3, was calculated by angle shift by SPR, which showed higher imprinting factor than the previous studies. We also validated the specificity of molecularly imprinted polymer loaded gold chip and compared the binding ability to estrogenicity known by in-vivo and in-vitro biological test. Molecular imprinting reflected the whole surface characteristics including three dimensional shape, types and location of functional groups, and distribution of interaction forces such as hydrogen bonding and van der Waals interaction. Therefore, MIP binding response could provide more insight on structure and estrogenic activity. Another purpose was to provide the basic data for future development of EDC screening array chip to find out various hormone activities at once. |
| Starting Page | 117 |
| Ending Page | 121 |
| Page Count | 5 |
| File Format | |
| ISSN | 20059752 |
| Journal | Toxicology and Environmental Health Sciences |
| Volume Number | 1 |
| Issue Number | 2 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2009-01-01 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Molecular imprinting Estrogen activity Selfassembled monolayer Surface plasmon resonance Pharmacology/Toxicology Environmental Health |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Toxicology |
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