NDLI: The Genome-Wide Influence on Human BMI Depends on Physical Activity, Life Course, and Historical Period

Content Provider	Springer Nature Link
Author	Guo, Guang Liu, Hexuan Wang, Ling Shen, Haipeng Hu, Wen
Copyright Year	2015
Abstract	In this analysis, guided by an evolutionary framework, we investigate how the human genome as a whole interacts with historical period, age, and physical activity to influence body mass index (BMI). The genomic influence is estimated by (1) heritability or the proportion of variance in BMI explained by genome-wide genotype data, and (2) the random effects or the best linear unbiased predictors (BLUPs) of genome-wide association studies (GWAS) data on BMI. Data were used from the Framingham Heart Study (FHS) in the United States. The study was initiated in 1948, and the obesity data were collected repeatedly over the subsequent decades. The analyses draw analysis samples from a pool of >8,000 individuals in the FHS. The hypothesis testing based on Pitman test, permutation Pitman test, F test, and permutation F test produces three sets of significant findings. First, the genomic influence on BMI is substantially larger after the mid-1980s than in the few decades before the mid-1980s within each age group of 21–40, 41–50, 51–60, and >60. Second, the genomic influence on BMI weakens as one ages across the life course, or the genomic influence on BMI tends to be more important during reproductive ages than after reproductive ages within each of the two historical periods. Third, within the age group of 21–50 and not in the age group of >50, the genomic influence on BMI among physically active individuals is substantially smaller than the influence on those who are not physically active. In summary, this study provides evidence that the influence of human genome as a whole on obesity depends on historical period, age, and level of physical activity.
Starting Page	1651
Ending Page	1670
Page Count	20
File Format	PDF
ISSN	00703370
Journal	Demography
Volume Number	52
Issue Number	5
e-ISSN	15337790
Language	English
Publisher	Springer US
Publisher Date	2015-08-29
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Obesity Genome-wide genotype Gene-environment interaction for obesity Period effect Age effect Demography Sociology Population Economics Medicine/Public Health Geography (general)
Content Type	Text
Resource Type	Article
Subject	Demography

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Is the Gene-Environment Interaction Paradigm Relevant to Genome-Wide Studies? The Case of Education and Body Mass Index

The interaction between physical activity and obesity gene variants in association with BMI: Does the obesogenic environment matter?

The Influence of Parental Education on Timing and Type of Union Formation: Changes Over the Life Course and Over Time in the Netherlands

Uncrossing the U.S. Black-White Mortality Crossover: The Role of Cohort Forces in Life Course Mortality Risk

Population Composition, Public Policy, and the Genetics of Smoking

The Family Life Course and Health: Partnership, Fertility Histories, and Later-Life Physical Health Trajectories in Australia

Paternal involvement with adolescents in intact families: The influence of fathers over the life course

The effects of race, ethnicity, and age on obesity

Education and survival: Birth cohort, period, and age effects

The Genome-Wide Influence on Human BMI Depends on Physical Activity, Life Course, and Historical Period

Similar Documents

Is the Gene-Environment Interaction Paradigm Relevant to Genome-Wide Studies? The Case of Education and Body Mass Index

The interaction between physical activity and obesity gene variants in association with BMI: Does the obesogenic environment matter?

The Influence of Parental Education on Timing and Type of Union Formation: Changes Over the Life Course and Over Time in the Netherlands

Uncrossing the U.S. Black-White Mortality Crossover: The Role of Cohort Forces in Life Course Mortality Risk

Population Composition, Public Policy, and the Genetics of Smoking

The Family Life Course and Health: Partnership, Fertility Histories, and Later-Life Physical Health Trajectories in Australia

Paternal involvement with adolescents in intact families: The influence of fathers over the life course

The effects of race, ethnicity, and age on obesity

Education and survival: Birth cohort, period, and age effects

The Genome-Wide Influence on Human BMI Depends on Physical Activity, Life Course, and Historical Period