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| Content Provider | Springer Nature Link |
|---|---|
| Author | Berman, Marc G. Nee, Derek Evan Casement, Melynda Kim, Hyang Sook Deldin, Patricia Kross, Ethan Gonzalez, Richard Demiralp, Emre Gotlib, Ian H. Hamilton, Paul Joormann, Jutta Waugh, Christian Jonides, John |
| Copyright Year | 2010 |
| Abstract | Individuals diagnosed with major depressive disorder (MDD) often ruminate about their depression and their life situations, impairing their concentration and performance on daily tasks. We examined whether rumination might be due to a deficit in the ability to expel negative information from short-term memory (STM), and fMRI was used to examine the neural structures involved in this ability. MDD and healthy control (HC) participants were tested using a directed-forgetting procedure in a short-term item recognition task. As predicted, MDD participants had more difficulty than did HCs in expelling negative, but not positive, words from STM. Overall, the neural networks involved in directed forgetting were similar for both groups, but the MDDs exhibited more spatial variability in activation in the left inferior frontal gyrus (a region critical for inhibiting irrelevant information), which may contribute to their relative inability to inhibit negative information. |
| Starting Page | 85 |
| Ending Page | 96 |
| Page Count | 12 |
| File Format | |
| ISSN | 15307026 |
| Journal | Cognitive, Affective, & Behavioral Neuroscience |
| Volume Number | 11 |
| Issue Number | 1 |
| e-ISSN | 1531135X |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2010-11-18 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | fMRI Interference Depression Short-term memory Rumination Cognitive Psychology Neurosciences |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cognitive Neuroscience Behavioral Neuroscience |
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