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Dopamine D$_{2}$ receptors mediate reversal learning in male C57BL/6J mice

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Dopamine D$_{2}$ receptors mediate reversal learning in male C57BL/6J mice

Content Provider	Springer Nature Link
Author	Kruzich, Paul J. Mitchell, Suzanne H. Younkin, Audrey Grandy, David K.
Copyright Year	2006
Abstract	Dopamine is critical for directing goal-oriented behavior. We investigated dopamine D$_{2}$ receptor involvement in reversal learning and reinforcement efficacy in mice lacking functional dopamine D$_{2}$ receptors and their heterozygous and wild-type littermates. Mice discriminated between two odors to receive a food reinforcer: One odor signaled a reinforcer (S$^{+}$); the other odor signaled no reinforcer (S$^{−}$). After mice learned the S$^{+}$/S$^{−}$ relationship, we inverted the reinforcement contingencies. The necessary number of trials to relearn the new reinforcement contingencies served as our index of reversal learning. Mice lacking functional dopamine D$_{2}$ receptors repeatedly failed to inhibit previously reinforced responses during reversal trials. In a separate experiment, mice responded for reinforcers on a progressive ratio schedule of reinforcement. Mice lacking functional dopamine D$_{2}$ receptors earned significantly fewer reinforcers than did heterozygous mice. Our results suggest that dopamine D$_{2}$ receptors regulate reversal learning and influence the reinforcing efficacy of natural rewards.
Starting Page	86
Ending Page	90
Page Count	5
File Format	PDF
ISSN	15307026
Journal	Cognitive, Affective, & Behavioral Neuroscience
Volume Number	6
Issue Number	1
e-ISSN	1531135X
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cognitive Psychology Neurosciences
Content Type	Text
Resource Type	Article
Subject	Cognitive Neuroscience Behavioral Neuroscience

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