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Multivariate analysis of immunohistochemical evaluation of protein expression in pancreatic ductal adenocarcinoma reveals prognostic significance for persistent Smad4 expression only

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Cellular Oncology : Volume 35, Issue 1, Supplement,February 2012

Cellular Oncology : Volume 35, Issue 1, February 2012

Cellular Oncology : Volume 34

Multivariate analysis of immunohistochemical evaluation of protein expression in pancreatic ductal adenocarcinoma reveals prognostic significance for persistent Smad4 expression only

Content Provider	Springer Nature Link
Author	Ottenhof, Niki A. Morsink, Folkert H. M. Kate, Fiebo Noorden, Cornelis J. F. Offerhaus, G. Johan A.
Copyright Year	2012
Abstract	Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis with a 5-year survival rate of <5% and an average survival of only 6 months. Although advances have been made in understanding the pathogenesis of PDAC in the last decades, overall survival has not changed. Various clinicopathological and immunohistological variables have been associated with survival time but the exact role that these variables play in relation to survival is not clear.To examine how the variables affected survival independently, multivariate analysis was conducted in a study group of 78 pancreatic ductal adenocarcinomas. The analysis included clinicopathological parameters and protein expression examined by immunohistochemistry of p53, Smad4, Axl, ALDH, MSH2, MSH6, MLH1 and PMS2. Lymph node ratio <0.2 (p = 0.004), tumor free resection margins (p = 0.044) and Smad4 expression (p = 0.004) were the only independent prognostic variables in the multivariate analysis. Expression of the other proteins examined was not significantly related to survival.Discrepancies with other studies in this regard are likely due to differences in quantification of immunohistochemical staining and the lack of multivariate analysis. It underscores the importance to standardize the methods used for the application of immunohistochemistry in prognostic studies.
Starting Page	119
Ending Page	126
Page Count	8
File Format	PDF
ISSN	22113428
Journal	Cellular Oncology
Volume Number	35
Issue Number	2
e-ISSN	22113436
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-02-18
Publisher Institution	International Society for Cellular Oncology
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Pancreatic ductal adenocarcinoma Immunohistochemistry Prognosis Long term survival Smad4 Resection margin Lymph node ratio Cancer Research Oncology Biomedicine general Pathology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Molecular Medicine Oncology

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