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Cellular Oncology : Volume 34

Aberrant microRNA expression and its implications in the pathogenesis of leukemias

Content Provider	Springer Nature Link
Author	Babashah, Sadegh Sadeghizadeh, Majid Tavirani, Mostafa Rezaei Farivar, Shirin Soleimani, Masoud
Copyright Year	2012
Abstract	MicroRNAs (miRNAs) are a class of non-coding, endogenous, small RNAs that negatively regulate gene expression by inducing degradation or translational inhibition of target mRNAs. Aberrant expression of miRNAs appears to be a common characteristic of hematological malignancies including leukemias.Here we review the available data supporting a role of aberrant expression of miRNAs in the pathogenesis of leukemias including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), and chronic lymphocytic leukemia (CLL).The expression signatures of miRNAs provide exciting opportunities in the diagnosis, prognosis, and therapy of leukemia. Since miRNAs can function as either oncogenes or tumor suppressor genes in leukemogenesis, the potential of using these small RNAs as therapeutic targets opens up new opportunities for leukemia therapy by either inhibiting or augmenting their activity.
Starting Page	317
Ending Page	334
Page Count	18
File Format	PDF
ISSN	22113428
Journal	Cellular Oncology
Volume Number	35
Issue Number	5
e-ISSN	22113436
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-09-07
Publisher Institution	International Society for Cellular Oncology
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	MicroRNA Expression signature Acute myeloid leukemia Acute lymphoblastic leukemia Chronic myeloid leukemia Chronic lymphocytic leukemia Oncology Pathology Biomedicine general Cancer Research
Content Type	Text
Resource Type	Article
Subject	Cancer Research Molecular Medicine Oncology

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