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| Content Provider | Springer Nature Link |
|---|---|
| Author | Puppin, Cinzia Passon, Nadia Frasca, Francesco Vigneri, Riccardo Tomay, Federica Tomaciello, Stefania Damante, Giuseppe |
| Copyright Year | 2011 |
| Abstract | Periostin expression is a feature of the epithelial-mesenchymal transition, which occurs during cancer progression. Previous reports indicate that periostin expression is related to tumour aggressiveness.In order to identify mechanisms regulating periostin expression in thyroid cancer, a panel of continuous thyroid cancer cell lines was investigated. Levels of posttranslational modifications of the H3 histone were investigated by chromatin immunoprecipitation. Moreover, treatment of cell lines with deacetylase inhibitors and transfection experiments were performed.Our insights show that levels of H3 histone acetylated at lysines 9 and 14 (which are epigenetic marks of active transcription) are not related to periostin mRNA levels. Moreover, treatment of WRO and FRO thyroid cancer cell lines with the deacetylase inhibitor tricostatin A (TSA) or suberoylanilide hydroxamic acid (SAHA) increases levels of acetylated H3 histone to periostin promoter however, unpredictably, reduces periostin mRNA levels. Interestingly, treatment of WRO cells with either TSA or SAHA increases levels of the H3 histone trimethylated at lysine 4, which is a different epigenetic mark of active transcription. Instead, data obtained by cell transfection indicate that ΔNp73, a member of p53 family selectively expressed in thyroid carcinomas, plays a role in activating periostin gene expression.Levels of epigenetic marks of active transcription do not contribute to regulation of periostin gene expression. The ΔNp73 effects suggest a novel molecular mechanism involved in thyroid cancer progression. |
| Starting Page | 131 |
| Ending Page | 140 |
| Page Count | 10 |
| File Format | |
| ISSN | 22113428 |
| Journal | Cellular Oncology |
| Volume Number | 34 |
| Issue Number | 2 |
| e-ISSN | 18758606 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2011-01-27 |
| Publisher Institution | International Society for Cellular Oncology |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Thyroid tumours Periostin Histone acetylation Gene expression p73 Pathology Biomedicine general Oncology Cancer Research |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Molecular Medicine Oncology |
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