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Journal of NeuroVirology : Volume 12

Journal of NeuroVirology : Volume 11

Journal of NeuroVirology : Volume 10

Journal of NeuroVirology : Volume 9

Journal of NeuroVirology : Volume 8

Journal of NeuroVirology : Volume 7

Glial activation and matrix metalloproteinase release in cerebral malaria

Content Provider	Springer Nature Link
Author	Szklarczyk, A. Stins, M. Milward, E. A. Ryu, H. Fitzsimmons, C. Sullivan, D. Conant, K.
Copyright Year	2007
Abstract	Although neurological symptoms associated with cerebral malaria (CM) are largely reversible, recent studies suggest that lasting neurological sequelae can occur. This may be especially true for children, in whom persistent deficits include problems with memory and attention. Because the malaria parasite is not thought to enter the brain parenchyma, lasting deficits are likely related to factors including the host response to disease. Studies with a rodent model, and with human postmortem tissue, suggest that glial activation occurs with CM. In this review, the authors will highlight studies focused on such activation in CM. Likely causes will be discussed, which include ischemia and activation of blood brain barrier endothelial cells. The potential consequences of glial activation will also be discussed, highlighting the possibility that glial-derived proteinases contribute to structural damage of the central nervous system (CNS). Of note, for the purposes of this focused review, glial activation will refer to the activation of astrocytes and microglial cells; discussion of oligodendroglial cells will not be included. In addition, although events thought to be critical to the pathogenesis of CM and glial activation will be covered, a comprehensive review of cerebral malaria will not be presented. Excellent reviews are already available, including Coltel {eaet al} (2004; Curr Neurovasc Res 1: 91–110), Medana and Turner (2006; Int J Parasitol 36: 555–568), and Hunt et al (2006; Int J Parasitol 36: 569–582).
Starting Page	2
Ending Page	10
Page Count	9
File Format	PDF
ISSN	13550284
Journal	Journal of NeuroVirology
Volume Number	13
Issue Number	1
e-ISSN	15382443
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neurosciences Virology Infectious Diseases Immunology Neurology
Content Type	Text
Resource Type	Article
Subject	Neurology Virology Neurology (clinical) Cellular and Molecular Neuroscience

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