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| Content Provider | Springer Nature Link |
|---|---|
| Author | Lamers, Susanna L. Salemi, Marco Galligan, Derek C. Morris, Alanna Gray, Rebecca Fogel, Gary Zhao, Li McGrath, Michael S. |
| Copyright Year | 2010 |
| Abstract | The interplay between pathology and human immunodeficiency virus (HIV) expansion in brain tissues has not been thoroughly assessed in the highly active antiretroviral therapy (HAART) era. HIV-associated dementia (HAD) is marked by progressive brain infection due to recruitment and migration of macrophages in brain tissues; however, the cellular and viral events occurring prior to HAD development and death are under debate. In this study, 66 brain tissues from 11 autopsies were analyzed to assess HIV-1 DNA concentration in brain tissues. In most patients without HAD, it was impossible to amplify HIV-1 from brain tissues. Amplifiable DNA was obtained from three cases of patients on HAART who died due to primary pathology other than HAD: (1) cardiovascular disease, a disease associated with HAART therapy; (2) bacterial infections, including Mycobacterium avium complex, rapid occurrence of extreme dementia; and (3) acquired immunodeficiency syndrome (AIDS)-related lymphoma with meningeal involvement. HIV-1 DNA was also amplified from multiple tissues of two HAD patients. Analysis of HIV-1 nef, gp120, and gp41 sequences showed reduced viral evolution within brain tissues for the non-HAD cases relative to patients with clinical and histological HAD. The present study is the first to show a potential correlation between HIV-1 evolutionary patterns in the brain and different neuropathologies. |
| Starting Page | 230 |
| Ending Page | 241 |
| Page Count | 12 |
| File Format | |
| ISSN | 13550284 |
| Journal | Journal of NeuroVirology |
| Volume Number | 16 |
| Issue Number | 3 |
| e-ISSN | 15382443 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2010-01-01 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | atherosclerosis CNS infection dementia genetic analysis HIV-1 nef macrophages neuropathology Neurosciences Virology Infectious Diseases Immunology Neurology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Virology Neurology (clinical) Cellular and Molecular Neuroscience |
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