NDLI: A New Approach to IRMPD Using Selective Ion Dissociation in a Quadrupole Ion Trap

Content Provider	Springer Nature Link
Author	Newsome, G. Asher Glish, Gary L.
Copyright Year	2011
Abstract	Infrared multiphoton photodissociation (IRMPD) in a quadrupole ion trap is not selective for a parent ion. Product ions are decreased in abundance by continuous sequential dissociation and may be lost below the low mass cut-off. The IRMPD process is made selective by resonantly exciting trapped ions into an axially offset laser path. Product ions form and collisionally relax out of the laser path to accumulate in the center of the trap. The technique, termed selective broadband (SB) IRMPD, limits sequential dissociation to preserve first generation product ion abundance. The abundances of larger product ions are maximized by completely dissociating the parent ion, but continuous sequential dissociation does not form small product ions below the low mass cut-off associated with conventional IRMPD. Smaller product ions are further increased in abundance in another tandem mass spectrum by performing sequential stages of SB-IRMPD, adjusting the trapping rf amplitude to dissociate larger product ions at the same q$_{z}$ range. Thermal assistance is used to perform SB-IRMPD at higher bath gas pressures for increased sensitivity.
Starting Page	207
Ending Page	213
Page Count	7
File Format	PDF
ISSN	10440305
Journal	Journal of The American Society for Mass Spectrometry
Volume Number	22
Issue Number	2
e-ISSN	18791123
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-01-15
Publisher Institution	The American Society for Mass Spectrometry
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Infrared multiphoton phodissociation Collision-induced dissociation Tandem mass-spectrometry Quadrupole ion trap Peptide Analytical Chemistry Proteomics Biotechnology Organic Chemistry Bioinformatics
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Structural Biology

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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