NDLI: Determination of the Deuterium Abundances in Water from 156 to 10,000 ppm by SIFT-MS

Content Provider	Springer Nature Link
Author	Španěl, Patrik Shestivska, Violetta Chippendale, Thomas W.E. Smith, David
Copyright Year	2011
Abstract	In response to a need for the measurement of the deuterium (D) abundance in water and aqueous liquids exceeding those previously recommended when using flowing afterglow mass spectrometry (FA-MS) and selected ion flow tube mass spectrometry (SIFT-MS) (i.e. 1000 parts per million, ppm), we have developed the theory of equilibrium isotopic composition of the product ions on which these analytical methods are based to encompass much higher abundances of D in water up to 10,000 ppm (equivalent to 1%). This has involved an understanding of the number density distributions of the H, D, $^{16}$O, $^{17}$O and $^{18}$O isotopes in the isotopologues of H$_{3}$O$^{+}$(H$_{2}$O)$_{3}$ hydrated ions (i.e. H$_{9}$O 4 + cluster ions) at mass-to-charge ratios (m/z) of 73, 74 and 75, the relative ion number densities of which represent the basis of FA-MS and SIFT-MS analyses of D abundance. Specifically, an extended theory has been developed that accounts for the inclusion of D atoms in the m/z 75 ions, which increasingly occurs as D abundance in the water is increased, and which is used as a reference signal for the m/z 74 ions in the measurement of D abundance. In order to investigate the efficacy of this theory, experimental measurements of deuterium abundance in standard mixtures were made by the SIFT-MS technique using two similar instruments and the results compared with the theory. It is demonstrated that the parameterization of experimental data can be used to formulate a simple calculation algorithm for real-time SIFT-MS measurements of D abundance to an accuracy of 1% below 1000 ppm and degrades to about 2% at 10,000 ppm.
Starting Page	179
Ending Page	186
Page Count	8
File Format	PDF
ISSN	10440305
Journal	Journal of The American Society for Mass Spectrometry
Volume Number	22
Issue Number	1
e-ISSN	18791123
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-01-21
Publisher Institution	The American Society for Mass Spectrometry
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Deuterium abundance Total body water Selected ion flow tube mass spectrometry SIFT-MS Stable isotopes Analytical Chemistry Proteomics Biotechnology Organic Chemistry Bioinformatics
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Structural Biology

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