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| Content Provider | Springer Nature Link |
|---|---|
| Author | Fischer, Joshua L. Lutomski, Corinne A. El Baba, Tarick J. Siriwardena Mahanama, Buddhima N. Weidner, Steffen M. Falkenhagen, Jana Allen, Matthew J. Trimpin, Sarah |
| Copyright Year | 2015 |
| Abstract | The analytical utility of a new and simple to use ionization method, matrix-assisted ionization (MAI), coupled with ion mobility spectrometry (IMS) and mass spectrometry (MS) is used to characterize a 2-armed europium(III)-containing poly(ethylene glycol) (Eu-PEG) complex directly from a crude sample. MAI was used with the matrix 1,2-dicyanobenzene, which affords low chemical background relative to matrix-assisted laser desorption/ionization (MALDI) and electrospray ionization (ESI). MAI provides high ion abundance of desired products in comparison to ESI and MALDI. Inductively coupled plasma-MS measurements were used to estimate a maximum of 10% of the crude sample by mass was the 2-arm Eu-PEG complex, supporting evidence of selective ionization of Eu-PEG complexes using the new MAI matrix, 1,2-dicyanobenzene. Multiply charged ions formed in MAI enhance the IMS gas-phase separation, especially relative to the singly charged ions observed with MALDI. Individual components are cleanly separated and readily identified, allowing characterization of the 2-arm Eu-PEG conjugate from a mixture of the 1-arm Eu-PEG complex and unreacted starting materials. Size-exclusion chromatography, liquid chromatography at critical conditions, MALDI-MS, ESI-MS, and ESI-IMS-MS had difficulties with this analysis, or failed. Graphical Abstract ᅟ |
| Starting Page | 2086 |
| Ending Page | 2095 |
| Page Count | 10 |
| File Format | |
| ISSN | 10440305 |
| Journal | Journal of The American Society for Mass Spectrometry |
| Volume Number | 26 |
| Issue Number | 12 |
| e-ISSN | 18791123 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2015-10-09 |
| Publisher Institution | The American Society for Mass Spectrometry |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Selective ionization matrix-assisted ionization ion mobility spectrometry mass spectrometry Europium Poly(ethylene glycol) Size-exclusion chromatography Liquid chromatography at critical conditions Electrospray ionization Matrix-assisted laser desorption/ionization Inductively coupled plasma-mass spectrometry Analytical Chemistry Biotechnology Organic Chemistry Proteomics Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Structural Biology |
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