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| Content Provider | Springer Nature Link |
|---|---|
| Author | Chen, S. Y. Wan, L. Huang, C. M. Huang, Y. C. Sheu, J. J. C. Lin, Y. J. Liu, S. P. Lan, Y. C. Lai, C. H. Lin, C. W. Tsai, C. H. Tsai, F. J. |
| Copyright Year | 2010 |
| Abstract | Rheumatoid arthritis (RA) is a chronic autoimmune disease and can lead to deformities and severe disabilities, due to irreversible damage of tendons, joints, and bones. A previous study indicated that a DNA repair system was involved in the development of RA. In this study, we investigated the association of four N-methylpurine-DNA glycosylase (MPG) gene polymorphisms (rs3176364, rs710079, rs2858056, and rs2541632) with susceptibility to RA in 384 Taiwanese individuals (192 RA patients and 192 control subjects). Our data show a statistically significant difference in genotype frequency distributions at rs710079 and rs2858056 SNPs between RA patients and control groups (P = 0.040 and 0.029, respectively). Our data also indicated that individuals with the GG genotype at rs2858056 SNP may have a higher risk of developing RA. In addition, compared with the haplotype frequencies between case and control groups, individuals with the GCGC haplotype appeared to be at a greater risk of RA progression (P = 0.003, OR = 1.75; 95% CI = 1.20–1.55). Our results suggest that rs710079 and rs2858056 polymorphisms and the GCGC haplotype in theMPG gene are associated with the risk of RA progression, and thus may be used as molecular markers of RA if they are confirmed by further research. |
| Starting Page | 519 |
| Ending Page | 521 |
| Page Count | 3 |
| File Format | |
| ISSN | 12341983 |
| Journal | Journal of Applied Genetics |
| Volume Number | 51 |
| Issue Number | 4 |
| e-ISSN | 21903883 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2010-01-01 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | haplotypes MPG N-methylpurine-DNA glycosylase rheumatoid arthritis single-nucleotide polymorphisms SNPs Life Sciences Animal Genetics and Genomics Human Genetics Microbial Genetics and Genomics Plant Genetics & Genomics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Medicine |
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