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| Content Provider | Springer Nature Link |
|---|---|
| Author | Asghar, Laila Fatima Ali Chandran, Sajeev |
| Copyright Year | 2011 |
| Abstract | A pH- and time-controlled drug delivery system with sigmoidal release profile was developed using Eudragit (L100 or S100) in combination with hydroxy ethyl cellulose (HEC) or hydroxy propyl cellulose (HPC) for sigmoidal release of indomethacin in the potential treatment of colon cancer. The effect of varying proportions of polymer type on sigmoidal release was evaluated. The prepared tablets were also characterized for physical characteristics, in vitro drug release, release kinetics, and stability on storage. The gastrointestinal transit of formulations was also investigated in human subjects. Results from in vitro release studies indicated that due to the presence of pH-responsive polymers, a pH- and time-dependent release pattern was observed, which was characterized by negligible drug release in first 4–6 h followed by controlled release for 14–16 h in alkaline pH. In vivo studies indicated that HPC-based formulations had satisfactory matrix strength to withstand gastric and colonic transit, while HEC-based tablets disintegrated during transit through the small intestine. All the formulations were stable on storage. It was concluded that such a matrix design has good potential for drug delivery to colon with controlled release. |
| Starting Page | 132 |
| Ending Page | 146 |
| Page Count | 15 |
| File Format | |
| ISSN | 2190393X |
| Journal | Drug Delivery and Translational Research |
| Volume Number | 1 |
| Issue Number | 2 |
| e-ISSN | 21903948 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2011-02-02 |
| Publisher Institution | Controlled Release Society |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Controlled release Colonic drug delivery Scintigraphy Pharmaceutical Sciences/Technology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmaceutical Science |
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