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Chronic norovirus infection in a patient with a past history of Burkitt lymphoma

Content Provider	Springer Nature Link
Author	Bruggink, Leesa D. Hayes, Lachlan Marshall, John A.
Copyright Year	2015
Abstract	The noroviruses are a leading cause of gastroenteritis worldwide. Although the illness is normally mild and self-limiting, there is a growing literature documenting the chronic excretion of norovirus in the immunocompromised. The aim of the current study was to examine the molecular features of chronic norovirus excretion in an immunocompromised patient with a past history of Burkitt lymphoma. During the 241 day course of the study from December 2013 to August 2014, seven faecal specimens were collected from the patient, tested for norovirus by RT-PCR and further analysed in the open reading frame (ORF) 1 and ORF 2 regions. All seven specimens were positive for norovirus by RT-PCR. Molecular sequencing in the polymerase (ORF 1) and capsid (ORF 2) regions indicated that the norovirus could be classified as GII.4 (2006b)/GII.4 (unknown). No significant mutation was found in the ORF 1 or ORF 2 regions analysed over the period of the study. The current report appears to be the first to document chronic norovirus excretion in a patient with a past history of Burkitt lymphoma. It is also the first to indicate long term norovirus excretion in a given individual need not involve major genetic change in key regions of the genome.
Starting Page	207
Ending Page	210
Page Count	4
File Format	PDF
ISSN	23473584
Journal	VirusDisease
Volume Number	26
Issue Number	3
e-ISSN	23473517
Language	English
Publisher	Springer India
Publisher Date	2015-08-20
Publisher Place	New Delhi
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Burkitt lymphoma Norovirus Chronic excretion Immunocompromised Microbiology Life Sciences Biochemistry Protein Structure Cell Biology
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Virology

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