NDLI: Characterization of genomic changes in the cervical pre-cancerous lesions and tumors induced by different types of human papillomaviruses

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VirusDisease : Volume 27, Issue 2, June 2016

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Characterization of genomic changes in the cervical pre-cancerous lesions and tumors induced by different types of human papillomaviruses

Content Provider	Springer Nature Link
Author	Grozdanov, Petar Hadjidekova, Savina Dimova, Ivanka Nikolova, Ivanka Toncheva, Draga Ganchev, Gancho Zlatkov, Victor Galabov, Angel S.
Copyright Year	2016
Abstract	Cervical carcinoma is the second most common malignancy among women in both incidence and mortality. Although much is known about the etiology and treatment of cervical cancer, the role of genetic alterations in the multistep pathway of cervical tumorigenesis is largely unknown. The aim of this study was to characterize the genomic changes in the cervical pre-cancerous lesions and tumors, induced by different types of human papillomaviruses. In this research was used the BlueGnome CytoChip oligo 2 × 105 K microarray for whole-genome oligo-array CGH. Microarray CGH analysis of 40 specimens was carried out—12 specimens from patients with early-stage squamous cell carcinomas; 19 specimens from patients with mild to moderate dysplasia and 9 with severe dysplasia. First we performed microarray CGH analysis of five DNA pools which contained the DNA from homogeneous groups of patients. The results revealed presence of micro chromosomal aberrations in chromosome region 14q11.2. According to the genome database these aberrations represent polymorphisms. Microarray analysis of DNA from 9 separate carcinoma lesions revealed a total of 26 aberrations in 14 chromosomes of nine patients. Our results showed the advantages of high-resolution chips in the clinical diagnosis of patients with cancerous and precancerous lesions caused by viral infection with HPV, but also highlight the need for extensive population studies revealing the molecular nature and clinical significance of different CNVs and the creation of detailed maps of variations in the Bulgarian population. This would facilitate extremely precise interpretation of specific genomic imbalances in the clinical aspect.
Starting Page	271
Ending Page	276
Page Count	6
File Format	PDF
ISSN	23473584
Journal	VirusDisease
Volume Number	27
Issue Number	3
e-ISSN	23473517
Language	English
Publisher	Springer India
Publisher Date	2016-08-09
Publisher Place	New Delhi
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Human papillomavirus Microarray CGH analysis Genomic aberration CNV Cervical cancer Microbiology Life Sciences Biochemistry Protein Structure Cell Biology
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Virology

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