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| Content Provider | Springer Nature Link |
|---|---|
| Author | Titov, I. I. Vorozheykin, P. S. |
| Copyright Year | 2011 |
| Abstract | Duplication of miRNAs is one of the modes of their evolution. This study demonstrates that human miRNAs arranged mostly in 5000-nt clusters and their copies are scattered randomly throughout the genome at an average distance of 4.3 × 10$^{6}$ bp. We compared the neighborhood of miRNAs copies with the transposable elements (TEs) and found that most miRNAs homologues (96%) propagate by DNA transposons and retroelements. Copies of primate-specific made1 elements containing the has-mir-548 miRNAs family contributed the most to this process. An analysis of made1’s evolution supports the earlier observation that these TEs emerged and multiplied explosively over the genome of a common ancestor and diverged later at average genomic rates. At that time, the modern copies of the has-mir-548 family appeared due to adaptive mutagenesis of some of the transposons copies; they were recruited into the silencing system. Nucleotide changes leading to transposon transformation into miRNAs genes and numerous miRNA copies may be helpful in predicting new miRNAs. |
| Starting Page | 308 |
| Ending Page | 314 |
| Page Count | 7 |
| File Format | |
| ISSN | 20790597 |
| Journal | Russian Journal of Genetics: Applied Research |
| Volume Number | 1 |
| Issue Number | 4 |
| e-ISSN | 20790600 |
| Language | English |
| Publisher | SP MAIK Nauka/Interperiodica |
| Publisher Date | 2011-08-21 |
| Publisher Place | Dordrecht |
| Access Restriction | Subscribed |
| Subject Keyword | miRNA transportable element DNA transposon made1 computer analysis structure evolution Human Genetics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Animal Science and Zoology Agronomy and Crop Science |
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