NDLI: Imaging in neurooncology

Content Provider	Springer Nature Link
Author	Jacobs, Andreas H. Kracht, Lutz W. Gossmann, Axel Rüger, Maria A. Thomas, Anne V. Thiel, Alexander Herholz, Karl
Copyright Year	2005
Abstract	Imaging in patients with brain tumors aims toward the determination of the localization, extend, type, and malignancy of the tumor. Imaging is being used for primary diagnosis, planning of treatment including placement of stereotaxic biopsy, resection, radiation, guided application of experimental therapeutics, and delineation of tumor from functionally important neuronal tissue. After treatment, imaging is being used to quantify the treatment response and the extent of residual tumor. At follow-up, imaging helps to determine tumor progression and to differentiate recurrent tumor growth from treatment-induced tissue changes, such as radiation necrosis. A variety of complementary imaging methods are currently being used to obtain all the information necessary to achieve the abovementioned goals. Computed tomography and magnetic resonance imaging (MRI) reveal mostly anatomical information on the tumor, whereas magnetic resonance spectroscopy and positron emission tomography (PET) give important information on the metabolic state and molecular events within the tumor. Functional MRI and functional PET, in combination with electrophysiological methods like transcranial magnetic stimulation, are being used to delineate functionally important neuronal tissue, which has to be preserved from treatment-induced damage, as well as to gather information on tumor-induced brain plasticity. In addition, optical imaging devices have been implemented in the past few years for the development of new therapeutics, especially in experimental glioma models. In summary, imaging in patients with brain tumors plays a central role in the management of the disease and in the development of improved imaging-guided therapies.
Starting Page	333
Ending Page	347
Page Count	15
File Format	PDF
ISSN	15455343
Journal	NeuroRX
Volume Number	2
Issue Number	2
Language	English
Publisher	Springer-Verlag
Publisher Date	2005-01-01
Publisher Institution	American Society for Experimental NeuroTherapeutics
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	Gliomas PET MRS FHBG FIAU molecular imaging Neurosciences Neurology Neurosurgery Neurobiology
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical)

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