NDLI: Strength Testing in Motor Neuron Diseases

Content Provider	Springer Nature Link
Author	Shefner, Jeremy M.
Copyright Year	2016
Abstract	Loss of muscle strength is a cardinal feature of all motor neuron diseases. Functional loss over time, including respiratory dysfunction, inability to ambulate, loss of ability to perform activities of daily living, and others are due, in large part, to decline in strength. Thus, the accurate measurement of limb muscle strength is essential in therapeutic trials to best understand the impact of therapy on vital function. While qualitative strength measurements show declines over time, the lack of reproducibility and linearity of measurement make qualitative techniques inadequate. A variety of quantitative measures have been developed; all have both positive attributes and limitations. However, with careful training and reliability testing, quantitative measures have proven to be reliable and sensitive indicators of both disease progression and the impact of experimental therapy. Quantitative strength measurements have demonstrated potentially important therapeutic effects in both amyotrophic lateral sclerosis and spinobulbar muscular atrophy, and have been shown feasible in children with spinal muscular atrophy. The spectrum of both qualitative and quantitative strength measurements are reviewed and their utility examined in this review.
Starting Page	154
Ending Page	160
Page Count	7
File Format	PDF
ISSN	19337213
Journal	NeuroRX
Volume Number	14
Issue Number	1
e-ISSN	18787479
Language	English
Publisher	Springer US
Publisher Date	2016-09-06
Publisher Institution	American Society for Experimental NeuroTherapeutics
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Motor neuron disease Spinal muscular atrophy Manual muscle testing TQNE Hand held dynamometry Neurosciences Neurology Neurosurgery Neurobiology
Content Type	Text
Resource Type	Article
Subject	Neurology (clinical) Pharmacology Pharmacology (medical)

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Strength Testing in Motor Neuron Diseases

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