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| Content Provider | Springer Nature Link |
|---|---|
| Author | Shahi, Mehdi H. Zazpe, Idoya Afzal, Mohammad Sinha, Subrata Rebhun, Robert B. Meléndez, Bárbara Rey, Juan A. Castresana, Javier S. |
| Copyright Year | 2014 |
| Abstract | Glioma constitutes one of the most common groups of brain tumors, and its prognosis is influenced by different genetic and epigenetic modulations. In this study, we demonstrated low or no expression of hedgehog interacting protein (HHIP) in most of the cell lines and primary glioma tumor samples. We further proceeded to promoter methylation study of this gene in the same cell lines and primary tumor samples and found 87 % (7/8) HHIP methylation in glioblastoma cell lines and 75 % (33/44) in primary tumor samples. These methylation pattern correlates with low or unexpressed HHIP in both cell lines and primary tumor samples. Our results suggest the possibility of epigenetic regulation of this gene in glioma, similarly to medulloblastoma, gastric, hepatic, and pancreatic cancers. Also, HHIP might be a diagnostic or prognostic marker in glioma and help to the detection of these tumors in early stages of disease. |
| Starting Page | 2383 |
| Ending Page | 2391 |
| Page Count | 9 |
| File Format | |
| ISSN | 10104283 |
| Journal | Tumor Biology |
| Volume Number | 36 |
| Issue Number | 4 |
| e-ISSN | 14230380 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2014-11-22 |
| Publisher Place | Dordrecht |
| Access Restriction | Subscribed |
| Subject Keyword | Human hedgehog interacting protein (HHIP) Glioma Glioblastoma promoter methylation Melting curve analysis-Meth (MCA-Meth) GLI1 Cancer Research |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Cancer Research |
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