NDLI: MiR-449a enhances radiosensitivity through modulating pRb/E2F1 in prostate cancer cells

Content Provider	Springer Nature Link
Author	Mao, Aihong Liu, Yang Wang, Yali Zhao, Qiuyue Zhou, Xin Sun, Chao Di, Cuixia Si, Jing Gan, Lu Zhang, Hong
Copyright Year	2015
Abstract	miR-449a, a novel tumor suppressor, is deregulated in various malignancies, including prostate cancer. Overexpression of miR-449a induces cell cycle arrest, apoptosis, and senescence, but its role in response to ionizing radiation and underlying molecular mechanism are still unknown. Here, we report that miR-449a enhances radiation-induced G2/M phase arrest and apoptosis through modulating pRb/E2F1 and sensitizes prostate cancer cells to X-ray radiation. In wild-type Rb PC-3 cells, overexpression of miR-449a enhances radiation-induced G2/M arrest and apoptosis and promotes the sensitivity to X-ray radiation. While mutant Rb DU-145 cells are resistant to the X-ray radiation despite in the presence of miR-449a. The cell cycle distribution of DU-145 cells is not significantly altered by miR-449a in the response to ionizing radiation. Furthermore, elevated miR-449a downregulates cell cycle regulator CDC25A and oncogene HDAC1. By targeting genes involved in controlling pRb/E2F1 activity, miR-449a regulates cell cycle progression and apoptosis and consequently enhances the radiosensitivity of PC-3 cells. Thus, miR-449a, as a miRNA component of the Rb pathway, promotes the radiosensitivity of PC-3 cells through regulating pRb/E2F1.
Starting Page	4831
Ending Page	4840
Page Count	10
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	37
Issue Number	4
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-10-31
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	miR-449a G2/M arrest Apoptosis pRb/E2F1 Radiosensitivity Prostate cancer Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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