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| Content Provider | Springer Nature Link |
|---|---|
| Author | Xue, Jun Niu, Yan Feng Huang, Jing Peng, Gang Wang, Li xia Yang, Yu Hui Li, Yun Qiao |
| Copyright Year | 2014 |
| Abstract | MicroRNAs (miRNAs) function as essential post-transcriptional modulators of gene expression involved in a wide range of physiologic and pathologic states, including cancer. Numerous miRNAs have been deregulated in hepatocellular carcinoma (HCC). Here, we investigated the role of miR-141 in HCC. Decreased expression of miR-141 was observed in both HCC tissues and cell lines. Ectopic overexpression of miR-141 reduced proliferation, migration, and invasion of HCC cells. E2F transcription factor 3 (E2F3) was confirmed to be a target of miR-141 in HCC cells. Moreover, restoration of E2F3 significantly reversed the tumor suppressive effects of miR-141. Our results suggest a critical role of miR-141 in suppressing metastasis of HCC cells by targeting E2F3. |
| Starting Page | 12103 |
| Ending Page | 12107 |
| Page Count | 5 |
| File Format | |
| ISSN | 10104283 |
| Journal | Tumor Biology |
| Volume Number | 35 |
| Issue Number | 12 |
| e-ISSN | 14230380 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2014-08-21 |
| Publisher Place | Dordrecht |
| Access Restriction | Subscribed |
| Subject Keyword | HCC miR-141 E2F3 Proliferation Migration Invasion Cancer Research |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Cancer Research |
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