NDLI: MicroRNA-128 inhibits EMT of human osteosarcoma cells by directly targeting integrin α2

Content Provider	Springer Nature Link
Author	Liu, Xinsheng Liang, Zhiyong Gao, Kehai Li, Huazhuang Zhao, Guangzong Wang, Shantao Fang, Jun
Copyright Year	2015
Abstract	Deregulated expression of miRNAs contributes to the development of osteosarcoma. The present study was to evaluate the level of miR-128 and integrin α2 (ITGA2) in osteosarcoma tissues and cells. We further investigated the molecular mechanisms of miR-128 and ITGA2 in osteosarcoma cell lines. In the present study, we found that miR-128 expression was down-regulated in osteosarcoma tissues and MG-63, U2OS, and SAOS-2 cells (all p < 0.001). By contrast, ITGA2 was up-regulated. Furthermore, we found that miR-128 overexpression suppressed cell migration and invasion of MG-63 cells. Mechanically, miR-128 overexpression inhibited epithelial-mesenchymal transition (EMT) of MG-63 cells. Importantly, we identified that the 3′-untranslated region (3′-UTR) of ITGA2 was a direct target of miR-128. Luciferase reporter assays confirmed that miR-128 binding to the 3′-UTR regions of ITGA2 inhibited the expression of ITGA2 in MG-63 cells. At the same time, overexpressed ITGA2 also reversed EMT inhibited by miR-128. In conclusion, this study suggested that high miR-128 expression suppressed osteosarcoma cell migration, invasion, and EMT development through targeting ITGA2, which may be recommended as a therapeutic target for osteosarcoma.
Starting Page	7951
Ending Page	7957
Page Count	7
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	37
Issue Number	6
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-12-24
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	miR-128 ITGA2 EMT Osteosarcoma Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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