NDLI: Expression pattern of BCCIP in hepatocellular carcinoma is correlated with poor prognosis and enhanced cell proliferation

Content Provider	Springer Nature Link
Author	Lin, Zhipeng Hu, Baoying Ni, Wenkai Mao, Xiaofei Zhou, Huiling Lv, Jiale Yin, Bihui Shen, Zhongyi Wu, Miaomiao Ding, Wensen Xiao, Mingbing Ni, Runzhou
Copyright Year	2016
Abstract	BCCIP was originally identified as a BRCA2- and CDKN1A- (Cip1/waf1/p21) interacting protein, also known as BCCIP. It has been reported to express in various types of cancers, including colorectal cancer (CRC), astrocytic brain tumors, and glioblastomas. However, the relationship between BCCIP expression and clinicopathological features of hepatocellular carcinoma (HCC) remains to be determined. Herein, we demonstrated that BCCIP was downregulated in clinical HCC tissues; its level was inversely correlated with multiple clinicopathological factors, such as tumor grade, tumor size, and Ki67 expression. Cox regression analysis of tumor samples revealed that BCCIP expression status was an independent prognostic factor for HCC patients’ poor survival. Our study also indicated that BCCIP shutdown reduces p21 expression and accelerates G1 to S progression of LO2 hepatocytes significantly. Moreover, there is an interaction between BCCIP and p53 in hepatic L02 cells, and the downregulation of p21 expression by BCCIP is in a p53-dependent way. These findings revealed that BCCIP may play a significant role for the determination of HCC progression through its role in regulating cell growth. Thus, our results suggest that BCCIP is of potential interest for prognostic marker and therapeutic target of HCC.
Starting Page	16305
Ending Page	16315
Page Count	11
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	37
Issue Number	12
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-11-10
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	BCCIP Hepatocellular carcinoma p53 Prognosis Cell proliferation Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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