NDLI: Influence of BCL2-938 C>A promoter polymorphism and BCL2 gene expression on the progression of breast cancer

Content Provider	Springer Nature Link
Author	Meka, Phanni Jarjapu, Sarika Vishwakarma, Sandeep Kumar Nanchari, Santhoshi Rani Cingeetham, Anuradha Annamaneni, Sandhya Mukta, Srinivasulu Triveni, B. Satti, Vishnupriya
Copyright Year	2015
Abstract	BCL2 (B-cell leukemia/lymphoma 2) gene functions as antiapoptotic regulatory element and known to be associated with tumorigenesis. The SNP-938 (C>A) (rs2279115), located in the inhibitory P2 promoter of the BCL2 gene, influences differential binding affinities of transcriptional factors thereby affecting BCL2 expression. The present study is an attempt to evaluate the association between BCL2(-938C>A) polymorphism and clinical characteristics of breast cancer patients as well as to analyze BCL2 expression and Ki67 proliferation index with respect to the genotypes. One hundred ten primary breast cancer tumor tissues were genotyped for -938 C>A polymorphism through PCR-RFLP method as well as evaluated for BCL2 expression and ki67 proliferation index by immunohistochemistry. Evaluation of apoptosis level was performed by flowcytometry. The results revealed that AA genotype was associated with an increased risk (AA Vs AC + CC) by 2.86-fold (p = 0.07) for breast cancer development which reflected in elevated A allele frequency also. AA genotype was found to be predominant among BCL2 positive tumors as compared to BCL2 negative tumors. Further, AA genotype was found to be associated with advanced stage tumors, node positive status, and high Ki67 proliferation index compared to CA and CC genotypes indicating that elevated expression of BCL2 gene in the presence of A allele might be associated with decreased apoptosis and enhanced proliferation rate. AA genotype of BCL2-938C>A polymorphism might influence BCL2 gene expression there by associated with elevated risk for breast cancer progression. Probably, failure of apoptosis due to enhanced expression and antiapoptotic protein BCL2 might promote malignant growth.
Starting Page	6905
Ending Page	6912
Page Count	8
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	37
Issue Number	5
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-12-11
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	BCL2 Apoptosis Immunohistochemistry Ki67 proliferation index Flow cytometry Breast cancer Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Influence of BCL2-938 C>A promoter polymorphism and BCL2 gene expression on the progression of breast cancer

Study of Regulatory Promoter Polymorphism (-938 C>A) of bcl2 Gene in Patients with Gastric Cancer

The BCL2-938 C > A promoter polymorphism is associated with risk group classification in children with acute lymphoblastic leukemia

A BCL2 promoter polymorphism rs2279115 is not associated with BCL2 protein expression or patient survival in breast cancer patients

Involvement of CASP3 promoter polymorphism (−1337 C > G) in the development and progression of non-small cell lung cancer

The BCL2-938 C > A promoter polymorphism is associated with risk group classification in children with acute lymphoblastic leukemia

A BCL2 promoter polymorphism rs2279115 is not associated with BCL2 protein expression or patient survival in breast cancer patients

piNET–An Automated Proliferation Index Calculator Framework for Ki67 Breast Cancer Images

Multicolor flow cytometric assessment of Ki67 expression and its diagnostic value in mature B-cell neoplasms

Influence of BCL2-938 C>A promoter polymorphism and BCL2 gene expression on the progression of breast cancer

Similar Documents

Influence of BCL2-938 C>A promoter polymorphism and BCL2 gene expression on the progression of breast cancer

Study of Regulatory Promoter Polymorphism (-938 C>A) of bcl2 Gene in Patients with Gastric Cancer

The BCL2-938 C > A promoter polymorphism is associated with risk group classification in children with acute lymphoblastic leukemia

A BCL2 promoter polymorphism rs2279115 is not associated with BCL2 protein expression or patient survival in breast cancer patients

Involvement of CASP3 promoter polymorphism (−1337 C > G) in the development and progression of non-small cell lung cancer

The BCL2-938 C > A promoter polymorphism is associated with risk group classification in children with acute lymphoblastic leukemia

A BCL2 promoter polymorphism rs2279115 is not associated with BCL2 protein expression or patient survival in breast cancer patients

piNET–An Automated Proliferation Index Calculator Framework for Ki67 Breast Cancer Images

Multicolor flow cytometric assessment of Ki67 expression and its diagnostic value in mature B-cell neoplasms

Influence of BCL2-938 C>A promoter polymorphism and BCL2 gene expression on the progression of breast cancer