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| Content Provider | Springer Nature Link |
|---|---|
| Author | Chen, Qi guang Zhou, Wei Han, Tao Du, Shu qi Li, Zhen hua Zhang, Zhe Shan, Guang yi Kong, Chui ze |
| Copyright Year | 2015 |
| Abstract | Prostate cancer is one of the biggest health problems for the aging male. To the present, the roles of dysregulated microRNAs in prostate cancer are still unclear. Here, we evaluated the anti-proliferative role of miR-378 in prostate cancer. And, we found that the expression of miR-378 was significantly downregulated in clinical prostate cancer tissues. In vitro assay suggested that overexpression of miR-378-suppressed prostate cancer cell migration and invasion promoted cell apoptosis. Furthermore, we identified and validated MAPK1 as a direct target of miR-378. Ectopic expression of MAPK1 rescues miR-378-suppressed cell migration and invasion. In vivo assay demonstrated that the stably miR-378-overexpressed prostate cancer cells displayed a significantly reduction in tumor growth. Taken together, our data suggested that miR-378 may act as a potential therapeutic target against human prostate cancer. |
| Starting Page | 2095 |
| Ending Page | 2103 |
| Page Count | 9 |
| File Format | |
| ISSN | 10104283 |
| Journal | Tumor Biology |
| Volume Number | 37 |
| Issue Number | 2 |
| e-ISSN | 14230380 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2015-09-07 |
| Publisher Place | Dordrecht |
| Access Restriction | Subscribed |
| Subject Keyword | Prostate cancer microRNA miR-378 MAPK1 Cancer Research |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Cancer Research |
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