NDLI: High expression of M3 muscarinic acetylcholine receptor is a novel biomarker of poor prognostic in patients with non-small cell lung cancer

Content Provider	Springer Nature Link
Author	Wu, Jun Zhou, Jinxu Yao, Lei Lang, Yaoguo Liang, Yingnan Chen, Lantao Zhang, Jinfeng Wang, Fengjiao Wang, Yanbo Chen, He Ma, Jianqun
Copyright Year	2013
Abstract	We assessed the expression of M3 receptor in non-small cell lung cancer (NSCLC) and determined its relationship with clinicopathological features and its impact on patient outcome. Specimens from 192 patients with NSCLC were investigated by immunohistochemistry for M3 receptor and Ki67 expression. Correlation between the expression of M3 receptor and Ki67 and various clinicopathological features of NSCLC patients was analyzed. We found that M3 receptor expression was gradually elevated from normal to metaplasia/dysplasia tissues to cancer tissues. Furthermore, there was a similar trend for Ki67 expression. Statistical analysis revealed that M3 receptor expression in tumor cells were correlated significantly with stage (P < 0.0001), histology type (P = 0.0003), Ki67 expression (P < 0.0001), tumor size (P < 0.0001), lymph node status (P < 0.0001), LVS invasion (P = 0.0002), and histology grade (P < 0.0001). Patients with M3 receptor high expression showed far lower disease-free survival (DFS) and overall survival (OS) rates than those with M3 receptor low expression. Multivariate Cox regression analysis demonstrated that high M3 receptor expression was an independent prognostic factor for both DFS and OS. High M3 receptor expression correlates with poor survival in NSCLC patients. M3 receptor expression may be related with tumor progression in NSCLC, indicating that M3 receptor may be a novel antineoplastic target in the future.
Starting Page	3939
Ending Page	3944
Page Count	6
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	34
Issue Number	6
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-07-10
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	M3 muscarinic acetylcholine receptor Non-small cell lung cancer Immunohistochemistry Survival Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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