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| Content Provider | Springer Nature Link |
|---|---|
| Author | Yang, Hea Jung Jung, Yune Suk Kim, Ki Suk Choi, Eun Kyeong Lim, Dong Jin Ahn, Kwang Seok Jung, Hee Jae Jung, Sung Ki Jang, Hyeung Jin |
| Copyright Year | 2011 |
| Abstract | Antibiotics are certainly beneficial to treat the bacterial infection. However, inappropriate use puts patients at danger for avoidable adverse drug reactions. This inappropriate use accelerates the emergence of resistance and potentially increases overall health-care costs. In oriental pharmacology, herbal medicines had been used as an antibiotic drug, but its antibiotic mechanism has not yet been proved completely. Here, we studied the antibiotic effects of Agrimonia pilosa on E. coli O157:H7. Especially, it is noteworthy that the antibiotic efficacy of the herb extract on three proven targets for a main antibiotic drug: bacterial cell wall biosynthesis, protein synthesis and DNA replication and repair. The results show the antibiotic effects through the inhibition of bacterial cell wall synthesis, folic acid synthesis, and multidrug efflux. |
| Starting Page | 299 |
| Ending Page | 310 |
| Page Count | 12 |
| File Format | |
| ISSN | 1738642X |
| Journal | Molecular & Cellular Toxicology |
| Volume Number | 7 |
| Issue Number | 3 |
| e-ISSN | 20928467 |
| Language | English |
| Publisher | The Korean Society of Toxicogenomics and Toxicoproteomics |
| Publisher Date | 2011-10-05 |
| Publisher Place | Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Agrimonia pilosa Antibiotic folA Cell wall inhibition cys sulfur metabolism Pharmacology/Toxicology Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology Pathology and Forensic Medicine |
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