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3-Aminotriazole protects against cobalt (II) chloride-induced cytotoxicity by inhibiting reactive oxygen species formation and preventing mitochondrial damage in HepG2 cells

Molecular & Cellular Toxicology : Volume 12

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Exploring potential biomarker responses to lithium in Daphnia magna from the perspectives of function and signaling networks

Content Provider	Springer Nature Link
Author	Kim, Hyo Jeong Yang, Jun Hyuek Kim, Hyun Soo Kim, Yeo Jin Jang, Wonhee Seo, Young Rok
Copyright Year	2017
Abstract	Intensive usage of electronic appliances containing lithium batteries causes an accumulation of e-trash. Environmental exposure to lithium batteries contaminates ecosystems. In air and water, the batteries form lithium hydroxide (LiOH) on their surfaces. LiOH enters the aquatic environment and contaminates the aquatic ecosystem by being absorbed into biological organisms. In this study, in order to identify meaningful potential biomarkers that appear in response to lithium, we measured significantly up- and down-regulated genes after LiOH exposure by conducting a microarray. In addition, we explored the functions of differentially expressed daphnia genes, and we conducted a comparative analysis in other species, Daphnia spp. to humans, then analyzed the signaling pathways using the human gene set derived from daphnia sequences that are differentially expressed in response to LiOH using the NCBI-BLAST tool and Pathway studio. As a result, we identified signaling pathways and suggested several potential biomarkers that are up- or down-regulated in response to lithium. This study may contribute to the development of a biomonitoring system which can detect the ecotoxicity of lithium. Furthermore, lithium toxicity in humans can be predicted, so the study may also provide potential biomarkers of lithium exposure in humans.
Starting Page	83
Ending Page	94
Page Count	12
File Format	PDF
ISSN	1738642X
Journal	Molecular & Cellular Toxicology
Volume Number	13
Issue Number	1
e-ISSN	20928467
Language	English
Publisher	The Korean Society of Toxicogenomics and Toxicoproteomics
Publisher Date	2017-03-30
Publisher Place	Incheon
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Lithium Daphnia magna Ecotoxicogenomics Comparative analysis Signaling pathway Cell Biology Pharmacology/Toxicology
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology Pathology and Forensic Medicine

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