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Genes & Genomics : Volume 31, Issue 2, April 2009

Genes & Genomics : Volume 31, Issue 1, February 2009

Analysis of the novel VNTR polymorphisms ofMUC8 gene

Content Provider	Springer Nature Link
Author	Lee, Ji Sun Kim, Ja Young Ahn, Eun Kyung Lee, Sang Yeop Jeong, Yun Hee Lee, Se Ra Leem, Sun Hee
Copyright Year	2009
Abstract	Analysis of mucin genes has identified the presence of several features that may represent important functional domains in mucin glycoproteins. In the central region of each mucin, there are a variable number of tandem repeats (VNTR; minisatellites). However, their genomic levels are unclear because of complex genomic properties. We report here the distribution of VNTR and polymorphic analysis ofMUC8. We searched for VNTR ofMUC8 using the Tandem Repeat Finder program and found nine VNTR motif. Six (MUC8 MS1∼MS6) among the nine VNTRs were evaluated in this study. Each VNTR inMUC8 region was analyzed in genomic DNA obtained from 200 unrelated individuals and multi-generational families. All VNTRs (MUC8 MS1, -MS2, -MS3, -MS4,-MS5 and -MS6) were genotyped as polymorphic. The degree of polymorphism within theMUC8-MS5 showed the highest heterozygosity (h = 0.786) in theMUC8 region. In order to perform a segregation analysis of the VNTRs inMUC8, we analyzed genomic DNA obtained from two generations of five families and from three generations of two families. Six of the polymorphic VNTRs were transmitted through meiosis following a Mendelian inheritance, which suggests that polymorphic VNTRs could be useful markers for paternity mapping and DNA fingerprinting.
Starting Page	235
Ending Page	241
Page Count	7
File Format	PDF
ISSN	19769571
Journal	Genes & Genomics
Volume Number	31
Issue Number	3
e-ISSN	20929293
Language	English
Publisher	Springer Netherlands
Publisher Date	2009-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Mucin MUC8 VNTR Polymorphism DNA typing marker Microbial Genetics and Genomics Plant Genetics & Genomics Animal Genetics and Genomics Human Genetics
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology

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