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| Content Provider | Springer Nature Link |
|---|---|
| Author | Catlin, Sandra N. Guttorp, Peter McCallie, Monica T. Abkowitz, Janis L. |
| Copyright Year | 2004 |
| Abstract | Female Safari cats are offspring of domestic and Geoffroy parents, and are balanced heterozygotes with equal numbers of Blood cells containing domestic and Geoffroy-type glucose 6-phosphate dehydrogenase (G6PD),an X-chromosome derived enzyme. In previous studies, however, we observed increasing percentages of Blood cells with Geoffroy G6PD in cats aged 4–12 years. Similarly, ratios of parental X-chromosome phenotypes greater than three to one are common in women over age 60, while women under 40 typically exhibit one to one ratios. Using a two-compartment hidden-Markov model of the distribution of phenotype in samples taken during the second stage of hematopoiesis (Blood cell production), we estimate, through simulation and mathematical calculation, the Geoffroy selective advantages necessary to reproduce the data obtained from female Safari cats. It is shown that small differences in the kinetics of hematopoietic stem cells (HSC), less than might be detected by in vitro assays, can explain the “clonal dominance” observed with aging in cats, and by extension, human females. Conceptually, hematopoiesis in females can be viewed as a competitive exclusion process in which two populations of HSC (defined by parental X-chromosome phenotype) compete for environmental resources. As in many ecological examples, dominance may occur only after long periods of time. |
| Starting Page | 216 |
| Ending Page | 235 |
| Page Count | 20 |
| File Format | |
| ISSN | 10857117 |
| Journal | Journal of Agricultural, Biological, and Environmental Statistics |
| Volume Number | 9 |
| Issue Number | 2 |
| e-ISSN | 15372693 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2004-01-01 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Birth-death process Carrying capacity Compartment model Ecological niche Stochastic model Hidden-Markov model Statistics for Life Sciences, Medicine, Health Sciences Agriculture Environmental Monitoring/Analysis Biostatistics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Applied Mathematics Statistics and Probability Environmental Science Agricultural and Biological Sciences Statistics, Probability and Uncertainty |
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