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| Content Provider | Springer Nature Link |
|---|---|
| Author | Saha, A. K. Mazumdar, J. Kohles, S. S. |
| Copyright Year | 2005 |
| Abstract | Dynamic extracellular matrix (ECM) synthesis is explored in a hypothesized engineered cartilage construct. Growth (α) and decay (β) rate parameters are developed from a previous engineered cartilage model. The presented mathematical model was constructed from the parameterized experimental data using a deterministic and stochastic examination of ECM synthesis based on a negative feedback control mechanism. A growth factor supplementation is incorporated in a probabilistic mathematical approach. The growth factor component modified an initial deterministic model through a Gaussian white noise fluctuation. As the primary constituents of ECM, the mathematical tool is intended to characterize the probable steady state distribution of glycosaminoglycan (GAG) and collagen molecules as well as mean mass accumulation at homeostasis. Computer simulation of the models is applied to reported data from four similar chondrocyte-polymer construct culture systems. The range in rate ratios reflect the differing nature of GAG and collagen synthesis (αGAG/βGAG=4.2 to 148.6; αcollagen/βcollagen=8.1 to 2590.4). This technique reduced the influencing synthesis factors to a few key descriptive parameters. Additional anabolic and catabolic factors may further be built into the models. |
| Starting Page | 97 |
| Ending Page | 104 |
| Page Count | 8 |
| File Format | |
| ISSN | 01589938 |
| Journal | Australasian Physics & Engineering Sciences in Medicine |
| Volume Number | 28 |
| Issue Number | 2 |
| e-ISSN | 18795447 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2005-01-01 |
| Publisher Place | Dordrecht |
| Access Restriction | Subscribed |
| Subject Keyword | glycosaminoglycan collagen extracellular matrix growth factor tissue engineering gaussian white noise probability density function cartilage Biomedicine general Biophysics and Biological Physics Medical and Radiation Physics Biomedical Engineering Theoretical, Mathematical and Computational Physics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Physics and Astronomy Biophysics Biomedical Engineering |
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