NDLI: Ion-counting nanodosimetry: current status and future applications

Content Provider	Springer Nature Link
Author	Schulte, R. Bashkirov, V. Garty, G. Leloup, C. Shchemelinin, S. Breskin, A. Chechik, R. Milligan, J. Grosswendt, B.
Copyright Year	2003
Abstract	There is a growing interest in the study of interactions of ionizing radiation with condensed matter at the nanometer level. The motivation for this research is the hypothesis that the number of ionizations occurring within short segments of DNA-size subvolumes is a major factor determining the biological effectiveness of ionizing radiation. A novel dosimetry technique, called nanodosimetry, measures the spatial distribution of individual ionizations in an irradiated low-pressure gas model of DNA. The measurement of nanodosimetric event size spectra may enable improved characterization of radiation quality, with applications in proton and charged-particle therapy, radiation protection, and space research. We describe an ion-counting nanodosimeter developed for measuring radiation-induced ionization clusters in small, wall-less low-pressure gas volumes, simulating short DNA segments. It measures individual radiation-induced ions, deposited in 1 Torr propane within a tissue-equivalent cylindrical volume of 2–4 nm diameter and up to 100 nm length. We present first ionization cluster size distributions obtained with 13.6 MeV protons, 4.25 MeV alpha particles and 24.8 MeV carbon nuclei in propane; they correspond to a wide LET range of 4–500 keV/μm. We are currently developing plasmid-based assays to characterize the local clustering of DNA damage with biological methods. First results demonstrate that there is increasing complexity of DNA damage with increasing LET. Systematic comparison of biological and nanodosimetric data will help us to validate biophysical models predicting radiation quality based on nanodosimetric spectra. Possible applications for charged particle radiation therapy planning are discussed.
Starting Page	149
Ending Page	155
Page Count	7
File Format	PDF
ISSN	01589938
Journal	Australasian Physics & Engineering Sciences in Medicine
Volume Number	26
Issue Number	4
e-ISSN	18795447
Language	English
Publisher	Springer Netherlands
Publisher Date	2003-01-01
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	nanodosimetry single-ion counting radiotherapy applications Biomedicine general Biophysics and Biological Physics Medical and Radiation Physics Biomedical Engineering Theoretical, Mathematical and Computational Physics
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Physics and Astronomy Biophysics Biomedical Engineering

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