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Energy Costs of Singular and Concomitant Pressure and Volume Overload Lesions

Content Provider	Springer Nature Link
Author	Phillips, Canek Simon Walker, Rachael L. Dasi, Lakshmi Prasad
Copyright Year	2014
Abstract	Severity assessment in concomitant hypertension (HT) and heart valve disease or multiple heart valve disease is vague, and there exists no established severity index. The objective of this study is to propose a theoretical framework to utilize the ventricular power overhead rates of HT, aortic regurgitation (AR), aortic stenosis (AS), and mitral regurgitation (MR) as a new means to assess severity, particularly under concomitant conditions. A lumped parameter model was utilized to evaluate the ventricular energy budget under normal, singular, and concomitant combinations of HT, AS, AR, and MR; and calculate energy overhead rate defined as the % increase in ventricular power output. Disease severity for each lesion was modeled at mild, moderate, and severe levels per AHA/ACC guidelines. The overhead rate for HT and AS were 15% (mild), 25% (moderate), and 45% (severe); AR and MR corresponded to 40% (moderate) and 100% (severe). The overhead rate as a function of regurgitant fraction was shown to be highly nonlinear. The overhead rate for concomitant lesions were 39% (mild HT+mild AS), 51% (mild HT+mild AR), 46% (mild HT+mild MR), 51% (mild AS+mild AR), 37% (mild AS+mild MR), and 44% (mild AR+mild MR). Power overhead under volume overload increases nonlinearly while that for pressure overload is linear. Concomitant lesions involving pressure (and volume?) overload produce a net overhead rate greater than the sum of individual lesions. Synergy in overhead rates is most with the presence of uncontrolled HT.
Starting Page	44
Ending Page	53
Page Count	10
File Format	PDF
ISSN	1869408X
Journal	Cardiovascular Engineering and Technology
Volume Number	5
Issue Number	1
e-ISSN	18694098
Language	English
Publisher	Springer US
Publisher Date	2014-01-04
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Energetics Severity Aortic stenosis Mitral regurgitation Hypertension Lumped parameter model Biomedical Engineering Cardiology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering Cardiology and Cardiovascular Medicine

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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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